Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors

When Zika virus emerged as a public health emergency there were no drugs or vaccines approved for its prevention or treatment. We used a high-throughput screen for Zika virus protease inhibitors to identify several inhibitors of Zika virus infection. We expressed the NS2B-NS3 Zika virus protease and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Abrams, Rachel P. M., Yasgar, Adam, Teramoto, Tadahisa, Lee, Myoung-Hwa, Dorjsuren, Dorjbal, Eastman, Richard T., Malik, Nasir, Zakharov, Alexey V., Li, Wenxue, Bachani, Muzna, Brimacombe, Kyle, Steiner, Joseph P., Hall, Matthew D., Balasubramanian, Anuradha, Jadhav, Ajit, Padmanabhan, Radhakrishnan, Simeonov, Anton, Nath, Avindra
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733812/
https://ncbi.nlm.nih.gov/pubmed/33229545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005463117
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