Transcriptional heterogeneity between primary adult grey and white matter astrocytes underlie differences in modulation of in vitro myelination

BACKGROUND: Multiple sclerosis (MS) is an inflammation-mediated demyelinating disease of the central nervous system that eventually results in secondary axonal degeneration due to remyelination failure. Successful remyelination is orchestrated by astrocytes (ASTRs) and requires sequential activation...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Werkman, Inge L., Dubbelaar, Marissa L., van der Vlies, Pieter, de Boer-Bergsma, Jelkje J., Eggen, Bart J. L., Baron, Wia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733297/
https://ncbi.nlm.nih.gov/pubmed/33308248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-02045-3
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