BRD4 inhibition sensitizes renal cell carcinoma cells to the PI3K/mTOR dual inhibitor VS-5584

Activation of the PI3K/AKT/mTOR pathway promotes the progression of renal cell carcinoma (RCC). This study tested the anti-RCC cell activity of the PI3K/mTOR dual inhibitor, VS-5584. We show that VS-5584 inhibited PI3K/AKT/mTORC1/2 activation in established (786-O and A498 lines) and primary RCC cel...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Xu, Ming, Xu, Lijun, Wang, Yin, Dai, Guangcheng, Xue, Boxin, Liu, Yuan-yuan, Zhu, Jianbing, Zhu, Jin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732329/
https://ncbi.nlm.nih.gov/pubmed/33051401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103723
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