VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer

Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor prognostic marker for many tumor types and confers...

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Main Authors: Hart, Stefan, Novotny-Diermayr, Veronica, Goh, Kee Chuan, Williams, Meredith, Tan, Yong Cheng, Ong, Lai Chun, Cheong, Albert, Ng, Bee Kheng, Amalini, Chithra, Madan, Babita, Nagaraj, Harish, Jayaraman, Ramesh, Pasha, Khalid M., Ethirajulu, Kantharaj, Chng, Wee Joo, Mustafa, Nurulhuda, Goh, Boon Cher, Benes, Cyril, McDermott, Ultan, Garnett, Mathew, Dymock, Brian, Wood, Jeanette M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588144/
https://ncbi.nlm.nih.gov/pubmed/23270925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0466
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