VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim

The PI3K/mTOR/AKT pathway is an integral regulator of survival and drug resistance in multiple myeloma (MM). VS-5584 was synthesized with dual-specific and equipotent activity against mTORC1/2 and all four Class I PI3K isoforms so as to durably inhibit this pathway. We show that VS-5584 is highly ef...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Mustafa, Nurulhuda, Ting Lee, Jeannie Xue, Adina Nee, Huey Fang, Bi, Chonglei, Chung, Tae-Hoon, Hart, Stefan, Chng, Wee Joo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2017
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731918/
https://ncbi.nlm.nih.gov/pubmed/29254208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21988
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