VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim

The PI3K/mTOR/AKT pathway is an integral regulator of survival and drug resistance in multiple myeloma (MM). VS-5584 was synthesized with dual-specific and equipotent activity against mTORC1/2 and all four Class I PI3K isoforms so as to durably inhibit this pathway. We show that VS-5584 is highly ef...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Mustafa, Nurulhuda, Ting Lee, Jeannie Xue, Adina Nee, Huey Fang, Bi, Chonglei, Chung, Tae-Hoon, Hart, Stefan, Chng, Wee Joo
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731918/
https://ncbi.nlm.nih.gov/pubmed/29254208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21988
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky