PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation

Despite therapeutic advancement, multiple myeloma (MM) remains incurable with drug resistance being one of the main challenges in the clinic. Myeloma cells possess high protein secretory load, leading to increased intracellular endoplasmic reticulum (ER) stress. Hence, they are vulnerable to further...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Teoh, Phaik Ju, Bi, Chonglei, Sintosebastian, Chirackal, Tay, Liang Seah, Fonseca, Rafael, Chng, Wee Joo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308692/
https://ncbi.nlm.nih.gov/pubmed/27533450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11241
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