VS-5584, a Novel PI3K-mTOR Dual Inhibitor, Inhibits Melanoma Cell Growth In Vitro and In Vivo

Melanomas cause over 76% of skin cancer deaths annually. Phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is important for melanoma initiation and progression. In the current study, we evaluated the potential anti-melanoma effect of VS-5584, a novel and...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Shao, Zheren, Bao, Qi, Jiang, Fangzhen, Qian, Huan, Fang, Quan, Hu, Xueqing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512677/
https://ncbi.nlm.nih.gov/pubmed/26204252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132655
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