Elevated levels of extracellular vesicles in progranulin‐deficient mice and FTD‐GRN Patients

OBJECTIVE: The goal of this study was to investigate the effect of progranulin insufficiency on extracellular vesicles (EVs), a heterogeneous population of vesicles that may contribute to progression of neurodegenerative disease. Loss‐of‐function mutations in progranulin (GRN) are a major cause of f...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Arrant, Andrew E., Davis, Skylar E., Vollmer, Rachael M., Murchison, Charles F., Mobley, James A., Nana, Alissa L., Spina, Salvatore, Grinberg, Lea T., Karydas, Anna M., Miller, Bruce L., Seeley, William W., Roberson, Erik D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732244/
https://ncbi.nlm.nih.gov/pubmed/33197149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.51242
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