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Anti-hepatitis C virus activity of novel β-d-2′-C-methyl-4′-azido pyrimidine nucleoside phosphoramidate prodrugs

BACKGROUND: 2′-C-methyl and 4′-azido nucleosides have previously demonstrated inhibition of hepatitis C virus (HCV) replication by targeting the RNA-dependent RNA polymerase NS5B. In an effort to discover new and more potent anti-HCV agents, we envisioned synthesizing nucleoside analogues by combini...

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Dettagli Bibliografici
Pubblicato in:Antivir Chem Chemother
Autori principali: Rondla, Ramu, Coats, Steven J, McBrayer, Tamara R, Grier, Jason, Johns, Melissa, Tharnish, Phillip M, Whitaker, Tony, Zhou, Longhu, Schinazi, Raymond F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732023/
https://ncbi.nlm.nih.gov/pubmed/19843980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP1400
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