A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance

We designed, synthesized, and identified two novel nonpeptidic HIV-1 protease inhibitors (PIs), GRL- 037 and GRL-044, containing P2-tetrahydropyrano-tetrahydrofuran (Tp-THF), P1-benzene and P1-methoxybenzene, respectively, and P2'-isopropyl-aminobenzothiazole (Ip-Abt), based on the structure of...

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Vydáno v:Glob Health Med
Hlavní autoři: Aoki, Manabu, Chang, Simon B., Das, Debananda, Martyr, Cuthbert, Delino, Nicole S., Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: National Center for Global Health and Medicine 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731189/
https://ncbi.nlm.nih.gov/pubmed/33330753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.35772/ghm.2019.01003
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