Citrullination-Resistant LL-37 Is a Potent Antimicrobial Agent in the Inflammatory Environment High in Arginine Deiminase Activity

LL-37, the only member of the mammalian cathelicidin in humans, plays an essential role in innate immunity by killing pathogens and regulating the inflammatory response. However, at an inflammatory focus, arginine residues in LL-37 can be converted to citrulline via a reaction catalyzed by peptidyl-...

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Pubblicato in:Int J Mol Sci
Autori principali: Bryzek, Danuta, Golda, Anna, Budziaszek, Joanna, Kowalczyk, Dominik, Wong, Alicia, Bielecka, Ewa, Shakamuri, Priyanka, Svoboda, Pavel, Pohl, Jan, Potempa, Jan, Koziel, Joanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730452/
https://ncbi.nlm.nih.gov/pubmed/33266231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239126
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