A novel biological role for PADs: Citrullination of cathelicidin LL-37 controls the immunostimulatory potential of cell-free DNA

LL-37, the only human cathelicidin which is released during inflammation, is a potent regulator of immune responses by facilitating delivery of oligonucleotides to intracellular TLR-9, thereby enhancing the response of human plasmacytoid dendritic cells (pDCs) to extracellular DNA. Although importan...

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Udgivet i:J Immunol
Main Authors: Wong, Alicia, Bryzek, Danuta, Dobosz, Ewelina, Scavenius, Carsten, Svoboda, Pavel, Rapala-Kozik, Maria, Lesner, Adam, Frydrych, Ivo, Enghild, Jan, Mydel, Piotr, Pohl, Jan, Thompson, Paul R., Potempa, Jan, Koziel, Joanna
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860981/
https://ncbi.nlm.nih.gov/pubmed/29475987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701391
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