Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor

Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD activity is observed in rheumatoid arthritis (RA), Alzheimer’s disease, multipl...

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Pubblicato in:Int J Mol Sci
Autori principali: Aliko, Ardita, Kamińska, Marta, Falkowski, Katherine, Bielecka, Ewa, Benedyk-Machaczka, Malgorzata, Malicki, Stanisław, Kozieł, Joanna, Wong, Alicia, Bryzek, Danuta, Kantyka, Tomasz, Mydel, Piotr
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539144/
https://ncbi.nlm.nih.gov/pubmed/31052493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20092174
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