Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape

Peptidylarginine deiminase (PPAD) is a virulence factor unique to pathogenic Porphyromonas species, especially P. gingivalis. Mechanistically, PPAD activity, in conjunction with Arg-specific gingipains, generates protein fragments with citrullinated C-termini. Such polypeptides are potential de novo...

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Publicat a:Sci Rep
Autors principals: Aliko, Ardita, Kamińska, Marta, Bergum, Brith, Gawron, Katarzyna, Benedyk, Małgorzata, Lamont, Richard J., Malicki, Stanisław, Delaleu, Nicolas, Potempa, Jan, Mydel, Piotr
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6147916/
https://ncbi.nlm.nih.gov/pubmed/30237466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32603-y
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