Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice

Basal cell carcinoma (BCC) originate from Hedgehog/Patched signaling-activated epidermal stem cells. However, the chemically induced tumorigenesis of mice with a CD4Cre-mediated biallelic loss of the Hedgehog signaling repressor Patched also induces BCC formation. Here, we identified the cellular or...

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Pubblicato in:Int J Mol Sci
Autori principali: Brandes, Nadine, Mitkovska, Slavica Hristomanova, Botermann, Dominik Simon, Maurer, Wiebke, Müllen, Anna, Scheile, Hanna, Zabel, Sebastian, Frommhold, Anke, Heß, Ina, Hahn, Heidi, Uhmann, Anja
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730243/
https://ncbi.nlm.nih.gov/pubmed/33291515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239295
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