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Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors

The mitochondrial Ca(2+) uptake in trypanosomatids shares biochemical characteristics with that of animals. However, the composition of the mitochondrial Ca(2+) uniporter complex (MCUC) in these parasites is quite peculiar, suggesting lineage-specific adaptations. In this work, we compared the inhib...

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Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Bertolini, Mayara S., Docampo, Roberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730205/
https://ncbi.nlm.nih.gov/pubmed/33297372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239316
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