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Different Sensitivity of Control and MICU1- and MICU2-Ablated Trypanosoma cruzi Mitochondrial Calcium Uniporter Complex to Ruthenium-Based Inhibitors

The mitochondrial Ca(2+) uptake in trypanosomatids shares biochemical characteristics with that of animals. However, the composition of the mitochondrial Ca(2+) uniporter complex (MCUC) in these parasites is quite peculiar, suggesting lineage-specific adaptations. In this work, we compared the inhib...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bertolini, Mayara S., Docampo, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730205/
https://ncbi.nlm.nih.gov/pubmed/33297372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239316
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