Pharmacokinetic and pharmacodynamic analysis of baloxavir marboxil, a novel cap-dependent endonuclease inhibitor, in a murine model of influenza virus infection

BACKGROUND: Baloxavir acid, the active form of the orally available prodrug baloxavir marboxil, is a novel cap-dependent endonuclease inhibitor of influenza virus. Baloxavir marboxil has been shown to rapidly reduce virus titres compared with oseltamivir in clinical studies. OBJECTIVES: We investiga...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Ando, Yoshinori, Noshi, Takeshi, Sato, Kenji, Ishibashi, Toru, Yoshida, Yuki, Hasegawa, Takahiro, Onishi, Motoyasu, Kitano, Mitsutaka, Oka, Ryoko, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729387/
https://ncbi.nlm.nih.gov/pubmed/33035324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa393
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