Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models

Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA synthesis of influenza viruses. In the present study, we evaluated the efficacy of BXM against influenza virus infection in mouse models. Single...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fukao, Keita, Ando, Yoshinori, Noshi, Takeshi, Kitano, Mitsutaka, Noda, Takahiro, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527232/
https://ncbi.nlm.nih.gov/pubmed/31107922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217307
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