Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models

Baloxavir marboxil (BXM) is an orally available small molecule inhibitor of cap-dependent endonuclease (CEN), an essential enzyme in the initiation of mRNA synthesis of influenza viruses. In the present study, we evaluated the efficacy of BXM against influenza virus infection in mouse models. Single...

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Veröffentlicht in:PLoS One
Hauptverfasser: Fukao, Keita, Ando, Yoshinori, Noshi, Takeshi, Kitano, Mitsutaka, Noda, Takahiro, Kawai, Makoto, Yoshida, Ryu, Sato, Akihiko, Shishido, Takao, Naito, Akira
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527232/
https://ncbi.nlm.nih.gov/pubmed/31107922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217307
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