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Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
BACKGROUND: Mutations that inactivate MarR reduce susceptibility to ciprofloxacin and competitive growth fitness in Escherichia coli. Both phenotypes are caused by overexpression of the MarA regulon, which includes the AcrAB-TolC drug efflux pump. OBJECTIVES: We asked whether compensatory evolution...
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| Publicado no: | J Antimicrob Chemother |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7729382/ https://ncbi.nlm.nih.gov/pubmed/33089314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa417 |
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