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Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

A fundamental feature of life is that ribosomes read the genetic code in messenger RNA (mRNA) as triplets of nucleotides in a single reading frame. Mutations that shift the reading frame generally cause gene inactivation and in essential genes cause loss of viability. Here we report and characterize...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Huseby, Douglas L., Brandis, Gerrit, Praski Alzrigat, Lisa, Hughes, Diarmaid
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022156/
https://ncbi.nlm.nih.gov/pubmed/31992637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919390117
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