טוען...
Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
BACKGROUND: Mutations that inactivate MarR reduce susceptibility to ciprofloxacin and competitive growth fitness in Escherichia coli. Both phenotypes are caused by overexpression of the MarA regulon, which includes the AcrAB-TolC drug efflux pump. OBJECTIVES: We asked whether compensatory evolution...
שמור ב:
| הוצא לאור ב: | J Antimicrob Chemother |
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| Main Authors: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7729382/ https://ncbi.nlm.nih.gov/pubmed/33089314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa417 |
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