Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

BACKGROUND: Mutations that inactivate MarR reduce susceptibility to ciprofloxacin and competitive growth fitness in Escherichia coli. Both phenotypes are caused by overexpression of the MarA regulon, which includes the AcrAB-TolC drug efflux pump. OBJECTIVES: We asked whether compensatory evolution...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Antimicrob Chemother
Asıl Yazarlar: Praski Alzrigat, Lisa, Huseby, Douglas L, Brandis, Gerrit, Hughes, Diarmaid
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729382/
https://ncbi.nlm.nih.gov/pubmed/33089314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa417
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller