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Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
A fundamental feature of life is that ribosomes read the genetic code in messenger RNA (mRNA) as triplets of nucleotides in a single reading frame. Mutations that shift the reading frame generally cause gene inactivation and in essential genes cause loss of viability. Here we report and characterize...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7022156/ https://ncbi.nlm.nih.gov/pubmed/31992637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919390117 |
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