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Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators

Human reticulocyte 15-lipoxygenase-1 (h15-LOX-1 or ALOX15) and platelet 12-lipoxygenase (h12-LOX or ALOX12) catalysis of docosahexaenoic acid (DHA) and the maresin precursor, 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-HpDHA), were investigated to determine their product profiles...

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Dettagli Bibliografici
Pubblicato in:Biochemistry
Autori principali: Freedman, Cody, Tran, Adrianne, Tourdot, Benjamin E., Kalyanaraman, Chakrapani, Perry, Steve, Holinstat, Michael, Jacobson, Matthew P., Holman, Theodore R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729281/
https://ncbi.nlm.nih.gov/pubmed/32324389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00233
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