Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1

Diabetic nephropathy (DN), a microvascular complication of diabetes, is the leading cause of end-stage renal disease worldwide. Multiple studies have shown that podocyte dysfunction is a central event in the progression of the disease. Beside chronic hyperglycemia, dyslipidemia can induce insulin re...

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Publicat a:Sci Rep
Autors principals: Denhez, Benoit, Rousseau, Marina, Spino, Crysta, Dancosst, David-Alexandre, Dumas, Marie-Ève, Guay, Andréanne, Lizotte, Farah, Geraldes, Pedro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728775/
https://ncbi.nlm.nih.gov/pubmed/33303821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78376-1
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