mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and type 2 diabetics. Podocyte dysfunction is postulated to be a critical event associated with proteinuria and glomerulosclerosis in glomerular diseases including DN. However, molecular mechanisms of podocyte dysf...

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Detalhes bibliográficos
Main Authors: Inoki, Ken, Mori, Hiroyuki, Wang, Junying, Suzuki, Tsukasa, Hong, SungKi, Yoshida, Sei, Blattner, Simone M., Ikenoue, Tsuneo, Rüegg, Markus A., Hall, Michael N., Kwiatkowski, David J., Rastaldi, Maria P., Huber, Tobias B., Kretzler, Matthias, Holzman, Lawrence B., Wiggins, Roger C., Guan, Kun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104745/
https://ncbi.nlm.nih.gov/pubmed/21606597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44771
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