Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

Chronic glomerular diseases, associated with renal failure and cardiovascular morbidity, represent a major health issue. However, they remain poorly understood. Here we have reported that tightly controlled mTOR activity was crucial to maintaining glomerular podocyte function, while dysregulation of...

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Detalhes bibliográficos
Main Authors: Gödel, Markus, Hartleben, Björn, Herbach, Nadja, Liu, Shuya, Zschiedrich, Stefan, Lu, Shun, Debreczeni-Mór, Andrea, Lindenmeyer, Maja T., Rastaldi, Maria-Pia, Hartleben, Götz, Wiech, Thorsten, Fornoni, Alessia, Nelson, Robert G., Kretzler, Matthias, Wanke, Rüdiger, Pavenstädt, Hermann, Kerjaschki, Dontscho, Cohen, Clemens D., Hall, Michael N., Rüegg, Markus A., Inoki, Ken, Walz, Gerd, Huber, Tobias B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104746/
https://ncbi.nlm.nih.gov/pubmed/21606591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44774
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