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Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by growth factors is increased by extracellular amino acids through yet-undefined mechanisms of amino acid transfer into endolysosomes. Because the endocytic process of macropinocytosis concentrates extracellular solutes...

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書目詳細資料
發表在:J Cell Biol
Main Authors: Yoshida, Sei, Pacitto, Regina, Yao, Yao, Inoki, Ken, Swanson, Joel A.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4602043/
https://ncbi.nlm.nih.gov/pubmed/26438830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201504097
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