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Growth factor signaling to mTORC1 by amino acid–laden macropinosomes
The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by growth factors is increased by extracellular amino acids through yet-undefined mechanisms of amino acid transfer into endolysosomes. Because the endocytic process of macropinocytosis concentrates extracellular solutes...
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| Опубликовано в: : | J Cell Biol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4602043/ https://ncbi.nlm.nih.gov/pubmed/26438830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201504097 |
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