Increased SHP-1 Protein Expression by High Glucose Levels Reduces Nephrin Phosphorylation in Podocytes

Nephrin, a critical podocyte membrane component that is reduced in diabetic nephropathy, has been shown to activate phosphotyrosine signaling pathways in human podocytes. Nephrin signaling is important to reduce cell death induced by apoptotic stimuli. We have shown previously that high glucose leve...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Denhez, Benoit, Lizotte, Farah, Guimond, Marie-Odile, Jones, Nina, Takano, Tomoko, Geraldes, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281738/
https://ncbi.nlm.nih.gov/pubmed/25404734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612721
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