The effect of injected dose on localized tumor accumulation and cardiac uptake of doxorubicin in a Vx2 rabbit tumor model using MR-HIFU mild hyperthermia and thermosensitive liposomes

When doxorubicin (DOX) is administered via lyso-thermosensitive liposomes (LTLD), mild hyperthermia enhances localized delivery to heated vs. unheated tumors. The optimal LTLD dose and the impact of different doses on systemic drug distribution are unknown. In this study, we evaluated local and syst...

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Pubblicato in:Int J Hyperthermia
Autori principali: Cheng, Bingbing, Bing, Chenchen, Staruch, Robert M., Shaikh, Sumbul, Staruch, Michelle Wodzak, Szczepanski, Debra, Williams, Noelle S., Laetsch, Theodore W., Chopra, Rajiv
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727403/
https://ncbi.nlm.nih.gov/pubmed/32892667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/02656736.2020.1812737
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