Longer heating duration increases localized doxorubicin deposition and therapeutic index in Vx2 tumors using MR-HIFU mild hyperthermia and thermosensitive liposomal doxorubicin

Thermosensitive liposomal doxorubicin (LTSL-Dox) combined with mild hyperthermia enhances the localized delivery of doxorubicin (Dox) within a heated region. The optimal heating duration and the impact of extended heating on systemic drug distribution are unknown. Here we evaluated local and systemi...

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Detalhes bibliográficos
Main Authors: Chenchen Bing, Pratik Patel, Robert M. Staruch, Sumbul Shaikh, Joris Nofiele, Michelle Wodzak Staruch, Debra Szczepanski, Noelle S. Williams, Theodore Laetsch, Rajiv Chopra
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2019-01-01
Colecção:International Journal of Hyperthermia
Assuntos:
targeted drug delivery
thermosensitive liposomal doxorubicin
mr-guided high intensity focused ultrasound
mild hyperthermia
therapeutic ratio
Acesso em linha:http://dx.doi.org/10.1080/02656736.2018.1550815
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