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DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation

DNA crosslinking agents are widely used in cancer chemotherapy; however, responses of normal tissues to these agents have not been widely investigated. We reveal in mouse interfollicular epidermis, mammary gland, and hair follicle epithelia that genotoxicity does not promote apoptosis but paradoxica...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Seldin, Lindsey, Macara, Ian G
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725994/
https://ncbi.nlm.nih.gov/pubmed/33058780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.09.021
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