Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage

ABSTRACT: Photooxidative damage and chronic innate immune activation have been implicated in retinal pigment epithelium (RPE) dysfunction, a process that underlies blinding diseases such as age-related macular degeneration (AMD). To identify a potential molecular link between these mechanisms, we in...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Brandstetter, Carolina, Mohr, Lena K. M., Latz, Eicke, Holz, Frank G., Krohne, Tim U.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510924/
https://ncbi.nlm.nih.gov/pubmed/25783493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-015-1275-1
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