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Improvement of muscular atrophy by AAV–SaCas9-mediated myostatin gene editing in aged mice

Muscle mass and area usually decrease with age, and this phenomenon is known as sarcopenia. This age-related atrophy correlates with insufficient levels of muscle cells differentiate and proliferate regulated by the TGF-β signaling pathway and the expression of E3s ubiquitin-protein ligase by the ag...

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Detalhes bibliográficos
Publicado no:Cancer Gene Ther
Main Authors: Weng, Shaoting, Gao, Feng, Wang, Juan, Li, Xingyu, Chu, Beibei, Wang, Jiang, Yang, Guoyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725670/
https://ncbi.nlm.nih.gov/pubmed/32398787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41417-020-0178-7
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