Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9

The chronic production of hepatitis B viral (HBV) antigens could cause inflammation and necrosis, leading to elevation of liver enzymes from necrotic hepatocytes, hepatitis, cirrhosis, hepatocellular carcinoma, and liver failure. However, no current treatment is capable of significantly reducing HBs...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Li, Hao, Sheng, Chunyu, Liu, Hongbo, Wang, Shan, Zhao, Jiangyun, Yang, Lang, Jia, Leili, Li, Peng, Wang, Ligui, Xie, Jing, Xu, Dongping, Sun, Yansong, Qiu, Shaofu, Song, Hongbin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141737/
https://ncbi.nlm.nih.gov/pubmed/30254645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02080
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