Single AAV-Mediated CRISPR-SaCas9 Inhibits HSV-1 Replication by Editing ICP4 in Trigeminal Ganglion Neurons

Herpes simplex keratitis (HSK) is the most common cause of corneal blindness in developed nations, caused by primary or recurrent herpes simplex virus 1 (HSV-1) infection of the cornea. Latent infection of HSV-1, especially in the trigeminal ganglion (TG), causes recurrence of HSV-1 infection. As an...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Methods Clin Dev
Auteurs principaux: Chen, Yuxi, Zhi, Shengyao, Liang, Puping, Zheng, Qi, Liu, Mengni, Zhao, Qi, Ren, Jian, Cui, Jun, Huang, Junjiu, Liu, Yizhi, Songyang, Zhou
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298336/
https://ncbi.nlm.nih.gov/pubmed/32577430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.011
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