Mitochondrial dysfunction triggers a catabolic response in chondrocytes via ROS-mediated activation of the JNK/AP1 pathway

Mitochondrial function is impaired in osteoarthritis (OA) but its impact on cartilage catabolism is not fully understood. Here, we investigated the molecular mechanism of mitochondrial dysfunction-induced activation of the catabolic response in chondrocytes. Using cartilage slices from normal and OA...

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Detalles Bibliográficos
Publicado en:J Cell Sci
Main Authors: Ansari, Mohammad Y., Ahmad, Nashrah, Voleti, Sriharsha, Wase, Saima J., Novak, Kimberly, Haqqi, Tariq M.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725611/
https://ncbi.nlm.nih.gov/pubmed/33097606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.247353
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