Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant, heterogeneous cancer with poor treatment options. We found that mitochondrial dysfunction and oxidative stress trigger a niche favoring cholangiocellular overgrowth and tumorigenesis. Liver damage, reactive oxygen species (ROS) and paracri...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Yuan, Detian, Huang, Shan, Berger, Emanuel, Liu, Lei, Gross, Nina, Heinzmann, Florian, Ringelhan, Marc, Connor, Tracy O., Stadler, Mira, Meister, Michael, Weber, Julia, Öllinger, Rupert, Simonavicius, Nicole, Reisinger, Florian, Hartmann, Daniel, Meyer, Rüdiger, Reich, Maria, Seehawer, Marco, Leone, Valentina, Höchst, Bastian, Wohlleber, Dirk, Jörs, Simone, Prinz, Marco, Spalding, Duncan, Protzer, Ulrike, Luedde, Tom, Terracciano, Luigi, Matter, Matthias, Longerich, Thomas, Knolle, Percy, Ried, Thomas, Keitel, Verena, Geisler, Fabian, Unger, Kristian, Cinnamon, Einat, Pikarsky, Eli, Hüser, Norbert, Davis, Roger J., Tschaharganeh, Darjus F., Rad, Roland, Weber, Achim, Zender, Lars, Haller, Dirk, Heikenwalder, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909318/
https://ncbi.nlm.nih.gov/pubmed/28609656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.05.006
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