In silico prediction of ARB resistance: A first step in creating personalized ARB therapy

Angiotensin II type 1 receptor (AT(1)R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT(1)R gene. The AT(1)R coding sequence contains over 100 nsSNPs; therefore, t...

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Udgivet i:PLoS Comput Biol
Main Authors: Anderson, Shane D., Tabassum, Asna, Yeon, Jae Kyung, Sharma, Garima, Santos, Priscilla, Soong, Tik Hang, Thu, Yin Win, Nies, Isaac, Kurita, Tomomi, Chandler, Andrew, Alsamarah, Abdelaziz, Kanassatega, Rhye-Samuel, Luo, Yun L., Botello-Smith, Wesley M., Andresen, Bradley T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725353/
https://ncbi.nlm.nih.gov/pubmed/33237899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007719
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