Načítá se...
Can Relative Binding Free Energy Predict Selectivity of Reversible Covalent Inhibitors?
Reversible covalent inhibitors have many clinical advantages over noncovalent or covalent drugs. However, apart from selecting a warhead, substantial efforts in design and synthesis are needed to optimize noncovalent interactions to improve target-selective binding. Computational prediction of bindi...
Uloženo v:
| Vydáno v: | J Am Chem Soc |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729052/ https://ncbi.nlm.nih.gov/pubmed/29124934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08938 |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|