Carregando...
Can Relative Binding Free Energy Predict Selectivity of Reversible Covalent Inhibitors?
Reversible covalent inhibitors have many clinical advantages over noncovalent or covalent drugs. However, apart from selecting a warhead, substantial efforts in design and synthesis are needed to optimize noncovalent interactions to improve target-selective binding. Computational prediction of bindi...
Na minha lista:
| Publicado no: | J Am Chem Soc |
|---|---|
| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729052/ https://ncbi.nlm.nih.gov/pubmed/29124934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08938 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|