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Azithromycin resistance mutations in Streptococcus pneumoniae as revealed by a chemogenomic screen

We report on the combination of chemical mutagenesis, azithromycin selection and next-generation sequencing (Mut-Seq) for the identification of small nucleotide variants that decrease the susceptibility of Streptococcus pneumoniae to the macrolide antibiotic azithromycin. Mutations in the 23S riboso...

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Detalhes bibliográficos
Publicado no:Microb Genom
Main Authors: Gingras, Hélène, Patron, Kévin, Leprohon, Philippe, Ouellette, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Microbiology Society 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725334/
https://ncbi.nlm.nih.gov/pubmed/33074087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mgen.0.000454
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