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Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing

OBJECTIVES: The objective of this study was to characterize chromosomal mutations associated with resistance to tetracycline in Streptococcus pneumoniae. METHODS: Chronological appearance of mutations in two S. pneumoniae R6 mutants (R6M1TC-5 and R6M2TC-4) selected for resistance to tetracycline was...

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Pubblicato in:J Antimicrob Chemother
Autori principali: Lupien, Andréanne, Gingras, Hélène, Bergeron, Michel G., Leprohon, Philippe, Ouellette, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472328/
https://ncbi.nlm.nih.gov/pubmed/25862682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv060
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