Structure of human GABA(B) receptor in an inactive state

Human GABA(B) G protein-coupled receptor (GPCR), a member of the class C family, mediates inhibitory neurotransmission and is implicated in epilepsy, pain, and addiction(1). A unique GPCR known to require heterodimerization for function(2–6), its two subunits, GABA(B1) and GABA(B2), are structurally...

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Publicado no:Nature
Main Authors: Park, Jinseo, Fu, Ziao, Frangaj, Aurel, Liu, Jonathan, Mosyak, Lidia, Shen, Tong, Slavkovich, Vesna N., Ray, Kimberly M., Taura, Jaume, Cao, Baohua, Geng, Yong, Zuo, Hao, Kou, Yongjun, Grassucci, Robert, Chen, Shaoxia, Liu, Zheng, Lin, Xin, Williams, Justin P., Rice, William J., Eng, Edward T., Huang, Rick K., Soni, Rajesh K., Kloss, Brian, Yu, Zhiheng, Javitch, Jonathan A., Hendrickson, Wayne A., Slesinger, Paul A., Quick, Matthias, Graziano, Joseph, Yu, Hongtao, Fiehn, Oliver, Clarke, Oliver B., Frank, Joachim, Fan, Qing R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725281/
https://ncbi.nlm.nih.gov/pubmed/32581365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2452-0
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