Structure of human GABA(B) receptor in an inactive state

Human GABA(B) G protein-coupled receptor (GPCR), a member of the class C family, mediates inhibitory neurotransmission and is implicated in epilepsy, pain, and addiction(1). A unique GPCR known to require heterodimerization for function(2–6), its two subunits, GABA(B1) and GABA(B2), are structurally...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Park, Jinseo, Fu, Ziao, Frangaj, Aurel, Liu, Jonathan, Mosyak, Lidia, Shen, Tong, Slavkovich, Vesna N., Ray, Kimberly M., Taura, Jaume, Cao, Baohua, Geng, Yong, Zuo, Hao, Kou, Yongjun, Grassucci, Robert, Chen, Shaoxia, Liu, Zheng, Lin, Xin, Williams, Justin P., Rice, William J., Eng, Edward T., Huang, Rick K., Soni, Rajesh K., Kloss, Brian, Yu, Zhiheng, Javitch, Jonathan A., Hendrickson, Wayne A., Slesinger, Paul A., Quick, Matthias, Graziano, Joseph, Yu, Hongtao, Fiehn, Oliver, Clarke, Oliver B., Frank, Joachim, Fan, Qing R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725281/
https://ncbi.nlm.nih.gov/pubmed/32581365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2452-0
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