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Manipulating the Tumor Microenvironment in Tumor Organoids Induces Phenotypic Changes and Chemoresistance

Tumors comprised a tightly surrounded tumor microenvironment, made up of non-cellular extracellular matrix (ECM) and stromal cells. Although treatment response is often attributed to tumor heterogeneity, progression and malignancy are profoundly influenced by tumor cell interactions with the surroun...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:iScience
Hauptverfasser: Dominijanni, Anthony, Devarasetty, Mahesh, Soker, Shay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724203/
https://ncbi.nlm.nih.gov/pubmed/33319176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101851
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