Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format

Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi molecules can be expressed in various precursor formats. The aim of this study was to determine the most effective format. To this end, we con...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Brachtlova, Tereza, van Ginkel, Jan-Willem, Luinenburg, Mark J., de Menezes, Renée X., Koppers-Lalic, Danijela, Pegtel, D. Michiel, Dong, Wenliang, de Gruijl, Tanja D., van Beusechem, Victor W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723779/
https://ncbi.nlm.nih.gov/pubmed/33335978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.10.012
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