Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format

Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi molecules can be expressed in various precursor formats. The aim of this study was to determine the most effective format. To this end, we con...

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Dades bibliogràfiques
Publicat a:Mol Ther Oncolytics
Autors principals: Brachtlova, Tereza, van Ginkel, Jan-Willem, Luinenburg, Mark J., de Menezes, Renée X., Koppers-Lalic, Danijela, Pegtel, D. Michiel, Dong, Wenliang, de Gruijl, Tanja D., van Beusechem, Victor W.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7723779/
https://ncbi.nlm.nih.gov/pubmed/33335978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.10.012
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